Upload your own De-novo mutation containing gene names or substitutions

Rank a list of Entrez Gene IDs Enter a set of gene names, choose a cellular context and expression threshold then press submit to investigate their evolutionary intolerance.

or try an example: Epi4K

Select the cell specificty:

eg: Central nervous system

Select the expression cutoff:

eg: 100TPM


Include RVIS
Investigate a set of substitutions Enter a set of substitutions and press submit to investigate their evolutionary intolerance.

or try an example: Epi4K

Select the cell specificty:

eg: Central nervous system

Select the expression cutoff:

eg: 100TPM


Please wait will the data is loaded...
Entry Protein Mutation FATHMM Prediction FATHMM Score Associated Gene EvoTol Percentile Hot or not? more...
Domain Damaging Count